LIFE WITH nOH MAY BE DIFFICULT DUE TO THE VICIOUS CYCLE OF nOH

The symptoms and consequences of neurogenic orthostatic hypotension (nOH) may impact a patient's activities of daily living. nOH symptoms range in severity, from dizziness to syncope.1-5 Patients may experience symptoms associated with nOH throughout the day following postural change, but the morning may be worse because of nocturnal diuresis.1,2,4-6

The unpredictability of symptomatic episodes may cause patients to fear their symptoms, which can lead to physical inactivity and cardiovascular deconditioning. A patient's nOH symptoms may worsen as a result.1,2,4

 

MANAGING nOH SYMPTOMS CAN BE A DAILY STRUGGLE

Patients living with nOH may experience symptoms that affect their daily lives. These symptoms may include dizziness and lightheadedness, with or without syncope.1-5 Some patients experiencing symptoms associated with nOH may have increased feelings of isolation, anxiety, and depression as a result of the vicious cycle of nOH.2,4,7 An nOH diagnosis may provide a path for appropriate symptom management.4

Patients with nOH may be restricted due to a fear of sudden symptomatic episodes upon postural change.2,4

Patients may have difficulty completing activities of daily living without assistance.2,4

Patients with nOH may lose their autonomy due to symptoms.2,4

References: 1. Freeman R. Neurogenic orthostatic hypotension. N Engl J Med. 2008;358(6):615-624. 2. Kaufmann H, Norcliffe-Kaufmann L, Palma JA. Droxidopa in neurogenic orthostatic hypotension. Expert Rev Cardiovasc Ther. 2015;13(8):875-891. 3. Kaufmann H, Malamut R, Norcliffe-Kaufmann L, et al. The Orthostatic Hypotension Questionnaire (OHQ): validation of a novel symptom assessment scale. Clin Auton Res. 2012;22(2):79-90. 4. Low PA. Neurogenic orthostatic hypotension: pathophysiology and diagnosis. Am J Manag Care. 2015;21(suppl 13):s248-s257. 5. Freeman R, Wieling W, Axelrod FB, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res. 2011;21(2):69-72. 6. Low PA, Singer W. Management of neurogenic orthostatic hypotension: an update. Lancet Neurol. 2008;7(5):451-458. 7. Perlmuter LC, Sarda G, Casavant V, et al. A review of orthostatic blood pressure regulation and its association with mood and cognition. Clin Auton Res. 2012;22(2):99-107.